Plant Transcription Factor Database
Previous version: v3.0
Linum usitatissimum
GRF Family
Species TF ID Description
Lus10000473GRF family protein
Lus10004455GRF family protein
Lus10008268GRF family protein
Lus10008916GRF family protein
Lus10009533GRF family protein
Lus10011558GRF family protein
Lus10011559GRF family protein
Lus10014380GRF family protein
Lus10015651GRF family protein
Lus10019274GRF family protein
Lus10019275GRF family protein
Lus10020352GRF family protein
Lus10028899GRF family protein
Lus10033236GRF family protein
Lus10033441GRF family protein
Lus10037668GRF family protein
GRF Family Introduction

Previously, we identified a novel rice gene, GROWTH-REGULATING FACTOR1 (OsGRF1), which encodes a putative transcription factor that appears to play a regulatory role in stem elongation. We now describe the GRF gene family of Arabidopsis thaliana (AtGRF), which comprises nine members. The deduced AtGRF proteins contain the same characteristic regions--the QLQ (Gln, Leu, Gln) and WRC (Trp, Arg, Cys) domains--as do OsGRF1 and related proteins in rice, as well as features indicating a function in transcriptional regulation. Most of the AtGRF genes are strongly expressed in actively growing and developing tissues, such as shoot tips, flower buds, and roots, but weakly in mature stem and leaf tissues. Overexpression of AtGRF1 and AtGRF2 resulted in larger leaves and cotyledons, as well as in delayed bolting of the inflorescence stem when compared to wild-type plants. In contrast, triple insertional null mutants of AtGRF1-AtGRF3 had smaller leaves and cotyledons, whereas single mutants displayed no changes in phenotype and double mutants displayed only minor ones. The alteration of leaf growth in overexpressors and triple mutants was based on an increase or decrease in cell size, respectively. These results indicate that AtGRF proteins play a role in the regulation of cell expansion in leaf and cotyledon tissues.

Kim JH, Choi D, Kende H.
The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis.
Plant J. 2003 Oct;36(1):94-104.
PMID: 12974814